Pepsin, i-enzyme enamandla kwincindi yesisu esetyisa iiproteni ezinjengenyama, amaqanda, iimbewu, okanye iimveliso zobisi.I-Pepsin yindlela evuthiweyo esebenzayo ye-zymogen (iprotheni engasebenziyo) i-pepsinogen.
Pepsinyaqatshelwa ngo-1836 yingcali ye-physiologist yaseJamani uTheodor Schwann.Kwi-1929 icrystallization kunye neprotheyini yendalo yachazwa yi-American biochemist uJohn Howard Northrop we-Rockefeller Institute for Medical Research.(UNorthrop kamva wafumana isabelo seBhaso leNobel leChemistry ngowe-1946 ngomsebenzi wakhe wokucoca ngempumelelo kunye nokuqaqambisa iienzymes.)
Amadlala kulwelwe lwe-mucous-membrane yesisu enza kwaye agcine i-pepsinogen.Iimpembelelo ezivela kwi i-vagus nerve kunye ne-hormone secretions ye-gastrin kunye ne-secretin ivuselela ukukhululwa kwe-pepsinogen kwisisu, apho ixutywe ne-hydrochloric acid kwaye iguqulelwe ngokukhawuleza kwi-enzyme esebenzayo i-pepsin.Amandla okugaya i-pepsin makhulu kakhulu kwi-acidity yejusi yesisu esiqhelekileyo (pH 1.5-2.5).Emathunjini i-asidi ye-gastric ingathathi hlangothi (pH 7), kwaye i-pepsin ayisasebenzi.
Kwindlela yokwetyisa i-pepsin ichaphazela kuphela ukuthotywa kancinci kweeproteni zibe ziiyunithi ezincinci ezibizwa ngokuba zii-peptides, ezithi ke zifunxwe emathunjini ziye egazini okanye zophulwe ngakumbi zii-enzymes zepancreatic.
Izixa ezincinci ze-pepsin zidlula ukusuka esiswini ukuya egazini, apho ziqhekeza ezinye zezona zinkulu, okanye zisengagatywanga, amaqhekeza eprotheyini anokuthi athathwe ngamathumbu amancinci.
Ukubuyela umva okungapheliyo kwe-pepsin, i-asidi, kunye nezinye izinto ezivela esiswini ukuya kummizo zenza isiseko seemeko ze-reflux, ngakumbi isifo se-gastroesophageal reflux kunye ne-laryngopharyngeal reflux (okanye i-reflux ye-extraesophageal).Ekugqibeleni, i-pepsin kunye ne-asidi zihamba yonke indlela ukuya kwi-larynx, apho zingabangela umonakalo kwi-laryngeal mucosa kwaye zivelise iimpawu ezivela kwi-hoarseness kunye nokukhwehlela okungapheliyo ukuya kwi-laryngospasm (ukutshatyalaliswa okuzenzekelayo kweentambo zezwi) kunye nomhlaza we-laryngeal.
Deebio's pepsinItsalwa kumgangatho ophezulu weporcine gastric mucosa ngetekhnoloji yethu yotsalo olukhethekileyo.Isetyenziswa ngokubanzi kwi-dyspepsia ebangelwa kukuthatha ngaphezulu kwe-protein foods.digestive hypofunction ngexesha lokuchacha kunye nokungabikho kwe-proteinase yesisu okubangelwa yi-atrophic gastritis engapheliyo, umhlaza wesisu kunye ne-anemia eyingozi.
Ukuya kuthi ga kwiminyaka engama-30 yophononongo lwezenzululwazi kunye nokuziqhelanisa noshishino, siye saseka iTekhnoloji ye-DEEBIO 3H eyodwa, sisebenzisa yonke inkqubo yokhuselo lwe-enzymatic. Itekhnoloji yolawulo oluphambili, ngokuvula okungonakalisi, ivusa i-zymogen, kwaye iqonde umsebenzi ophezulu, ukucoceka okuphezulu kunye nokuzinza okuphezulu kweemveliso ze-bio-enzyme.
Ixesha lokuposa: Aug-16-2022